FAB, FCM Evaluation of related flow cytometry parameters with FAB subtype of acute myeloid leukemia associated with histological assessment

Abstract

The acute leukemia is a group of malignant disorders of the haemopoietic cells, characteristically related with increases of number of leucocytes in the blood. The present study is aimed to evaluation the expression of immunophenic antibodies which used on blast cells to diagnosis and classification acute leukemia by flow cytometry to define their relationship with age, gender and French-American–British (FAB) subtypes, and assessment complete blood count (CBC) including white blood cells WBCs, hemoglobin HGB, and  platelets PLTs, addition to define histological changes of bone marrow biopsy (BMB) of acute leukemia patients. This study included 73 patients were newly diagnosed with acute myeloid leukemia (AML), 60 of them was adults (range 15 –77 years), and the other 13 cases were children (range 1–14 years). The patients divided into three groups: 15-35, 36-55, and 56-77 years, while children patients divided into: 0-4, 5-8 and 9-14 years. The results shown that fever and paleness were the most common clinical feature among acute myeloid leukemia patients ( adults and children).