Study of the histological effect of liver of white mice experimentally infected with A. fumigatus and treated with Amphotericin B and Trametes sp.

Abstract

This study done to investigate the pathohistological lesions in the liver of white mice infected with Aspergillus fumigatus by two main procedures: intraperitoneal injection, nasal implantation and an oral attempt to treat them with the antifungal AmB and the Trametes sp.The result show that A.fumigatus led to the occurrence of tissue changes represented by the occurrence of degeneration necrosis of hepatocytes hemorrhage large infiltration of inflammatory cells  and separation of lining endothelial cells of central vein, WhiصًًًًصصصWwqqaooinckkkkle liver of groups of mice that infected with A.fumigatus and treated with the antifungal AmB and the Trametes sp it showed improvement as degeneration and necrosis of number of hepatocytes. Pycknotic nuclei, enlargement number of Kupffer cells, expansion of some blood sinuses, another histological sections showed the semi normal liver tissue.