Bacterial co-infection associated with patients suffering from SARS-CoV-2

Abstract

Patients with the new coronavirus disease severe acute respiratory syndrome (SARSCoV-2) may be suffering from bacterial infections. The detection of immunoglobulin including IgM and IgG could be provide information on the time of COVID-19 infection. To define and explore the bacterial co-infections in patients with COVID-19 infection, the level of IgM and IgG were determined as well as the level of C-reactive protein. SARS CoV-2 infections were diagnosed as well as bacterial co-infection in Zanko private hospital in Erbil. The samples included both male and female, with an average age of 18-50 years. The antigen-tests were used to detect coronavirus antibodies. Furthermore, the concentration of C-reactive protein was identified by measuring photometric at wavelength 546 nm of antigen-antibody reaction. The reaction was between human CRP antibodies that bound to polystyrene particles and CRP present in the samples.  The study showed positive results for both antibodies, but the level of IgM and IgG were low in the first week and after two weeks.

The results are showed a high level of C-reactive protein in the first and after two weeks, this could be referring to inflammation in patient’s body. The cause of inflammation was investigated by diagnosis the bacterial co-infection. It is found that 25 patients of total group (100) were sever from bacterial co-infection. There were gram positive and negative bacteria. Staphylococcus aureus which represents 40%, Escherichia coli (28%), Streptococcus pneumoniae (12%), both Klebsiella pneumoniae and Pseudomonas aeruginosa which represents (8%). Finally, Staphylococcus epidermidis (4%). In conclusion, more tests to find out the cause of inflammation are required because the CRP test does not describe the pathogen that cause the inflammation. In conclusion, the study demonstrated that the CRP test does not explain the microbe that cause or location of the inflammation. Therefore, is required more tests to find out the cause of inflammation