Spectrophotometric determination of Diazepam and Propranolol hydrochloride in pharmaceutical by dual wavelengths method
DOI:
https://doi.org/10.54153/sjpas.2020.v2i2.108Keywords:
Diazepam DZP, Propranolol PRO, Dual wavelengths.Abstract
A new, sensitive, accurate and fast spectrophotometric method for determination of Diazepam DZP and Propranolol hydrochloride PRO drugs was developed. The method based on the calculation of the difference in absorbance at dual wavelengths. The linearity of the method was between 5-45 µg/ml for the DZP drug and 5-20 µg/ml for the PRO drug. The optioned recovery percentage Rec was (101.0398-97.5947) % for DZP and (99.3272-101.0398) % for PRO. The relative standard deviation RSD % (0.2928-0.0587) % for DZP and (0.1617-1.0830) % PRO. LOD was 0.0439 µg/ml for DZP and 0.1624 µg/ml for PRO. The LOQ was 0.1463 µg/ml DZP µg/ml PRO. and molar absorptivity was 17283.718 L/mol.cm DZP and 9672.66 L/mol.cm PRO. The method was applied to the determination of DZP and PRO in Pharmaceutical.
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