The development and progression of non-alcoholic fatty liver disease are influenced by adipose tissue pro-inflammatory cytokines. (Review Article)

Authors

  • Mohammed Asaad Mahdi Department of Chemistry, College of Science, University of Diyala
  • Khalid Shaalan Sahab Department of Chemistry, College of Science, University of Diyala
  • Waseem Yousif M AL-dulaimy Department of Chemistry, College of Science, University of Diyala

DOI:

https://doi.org/10.54153/sjpas.2023.v5i2.490

Keywords:

pro-inflammatory cytokines, Non-alcoholic fatty liver disease, overweight, obesity, adipose tissue.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a disorder where persons who don't drink alcohol have an increase in liver fat. NAFLD has been connected to many variables. If left untreated, it can worsen into a type of non-alcoholic steatohepatitis (NASH). In all types of inflammatory illnesses, cytokines play a significant role. Inflammation is sparked by pro-inflammatory cytokines released by immune system cells and several other cell types, including adipocytes. According to the body mass index (BMI) of NAFLD patients, we evaluated the association between pro-inflammatory cytokines and progression of NAFLD in this review. The pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), transforming growth factor-1 (TGF-1), and interleukins (IL)-1 and -6 were shown to be increased in NAFLD patients compared to those who were healthy, the levels were much higher. In conclusion, there is a significant connection between inflammation and NAFLD and an increase in pro-inflammatory cytokines in overweight or obese people.

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Published

2023-06-30

How to Cite

Asaad Mahdi, M. ., Shaalan Sahab, K. ., & Yousif M AL-dulaimy, W. . (2023). The development and progression of non-alcoholic fatty liver disease are influenced by adipose tissue pro-inflammatory cytokines. (Review Article). Samarra Journal of Pure and Applied Science, 5(2), 71–82. https://doi.org/10.54153/sjpas.2023.v5i2.490

Issue

Vol. 5 No. 2 (2023): Samarra Journal of Pure and Applied Science

Section

Chemistry

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