The development and progression of non-alcoholic fatty liver disease are influenced by adipose tissue pro-inflammatory cytokines. (Review Article)
Keywords:pro-inflammatory cytokines, Non-alcoholic fatty liver disease, overweight, obesity, adipose tissue.
Non-alcoholic fatty liver disease (NAFLD) is a disorder where persons who don't drink alcohol have an increase in liver fat. NAFLD has been connected to many variables. If left untreated, it can worsen into a type of non-alcoholic steatohepatitis (NASH). In all types of inflammatory illnesses, cytokines play a significant role. Inflammation is sparked by pro-inflammatory cytokines released by immune system cells and several other cell types, including adipocytes. According to the body mass index (BMI) of NAFLD patients, we evaluated the association between pro-inflammatory cytokines and progression of NAFLD in this review. The pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), transforming growth factor-1 (TGF-1), and interleukins (IL)-1 and -6 were shown to be increased in NAFLD patients compared to those who were healthy, the levels were much higher. In conclusion, there is a significant connection between inflammation and NAFLD and an increase in pro-inflammatory cytokines in overweight or obese people.
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