Spectrophotometric determination of dapsone in Schiff base in pharmaceutical formulation by elemental complex method

Authors

  • Sabreen Shakir Mahmood Department of Applied Chemistry, College of Applied Science, University of Samarra
  • Eman Diab Ahmed Department of Chemistry, College of Education, University of Samarra
  • Liqaa Hussein Alwan Department of Chemistry, College of Education, University of Samarra

DOI:

https://doi.org/10.54153/sjpas.2023.v5i4.515

Keywords:

Dapsone, Cobalte Chloride Hexahydrate, Schiffs base and Metal complex

Abstract

The research included the development of a new and sensitive spectroscopic method for the determination of dapsone in aqueous media. The method depends on the interaction of the Schiff base of the drug dapsone with the reagent aqueous cobalt chloride to give a light-yellow complex whose absorption intensity depends on the concentration of dapsone in the Schiff base and gives the highest absorption at the wavelength of 354 nm. Legal limits are between         0.3-3 μg. mL-1 of dapsone, and the molar absorbance was 1.2812×104      L. mol-1. cm-1, the recovery rate is 101.2929%, and the relative standard deviation does not exceed 0.2306%, with a detection limit of 0.0481 μg. mL-1, and the method was applied in the determination of dapsone in its drug preparation in the form of tablets.

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Published

2023-12-30

How to Cite

Mahmood, S. S., Ahmed, E. D., & Alwan, L. H. (2023). Spectrophotometric determination of dapsone in Schiff base in pharmaceutical formulation by elemental complex method. Samarra Journal of Pure and Applied Science, 5(4), 13–23. https://doi.org/10.54153/sjpas.2023.v5i4.515

Issue

Vol. 5 No. 4 (2023): Samarra Journal of Pure and Applied Science

Section

Chemistry

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