Spectrophotometric determination of dapsone in Schiff base in pharmaceutical formulation by elemental complex method
DOI:
https://doi.org/10.54153/sjpas.2023.v5i4.515Keywords:
Dapsone, Cobalte Chloride Hexahydrate, Schiffs base and Metal complexAbstract
The research included the development of a new and sensitive spectroscopic method for the determination of dapsone in aqueous media. The method depends on the interaction of the Schiff base of the drug dapsone with the reagent aqueous cobalt chloride to give a light-yellow complex whose absorption intensity depends on the concentration of dapsone in the Schiff base and gives the highest absorption at the wavelength of 354 nm. Legal limits are between 0.3-3 μg. mL-1 of dapsone, and the molar absorbance was 1.2812×104 L. mol-1. cm-1, the recovery rate is 101.2929%, and the relative standard deviation does not exceed 0.2306%, with a detection limit of 0.0481 μg. mL-1, and the method was applied in the determination of dapsone in its drug preparation in the form of tablets.
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