Spectrophotometric determination of dapsone by oxidative coupling method using trifluoperazine hydrochloride reagent

Authors

  • Batool Mansoor Zaean Department of Chemistry, College of Education for Girls, University of Tikrit
  • Israa Talib Humeidy Department of Chemical Engineering, College of Engineering, University of Tikrit
  • Mohamed Salem Abdelaziz Department of Chemistry, College of Education for Girls, University of Tikrit

DOI:

https://doi.org/10.54153/sjpas.2024.v6i1.593

Keywords:

Dapson, Trifluoperazine hydrochloride, Oxidative Coupling

Abstract

A sensitive and simple spectrophotometric method was used for the determination of dapsone (DAP) in aqueous media. The method depended on the oxidative coupling reaction that occurs by oxidizing dapsone with potassium periodate, where an orange product is formed upon conjugation with Trifluoperazine hydrochloride reagent (TFPH) which gave the highest absorbance at 498 nm, and the limits of Beer's law ranged between 3.125 - 68.75 μg/mL, the molar adsorption coefficient is 0.4643 × 104 L.mol-1. cm-1, the Sandel significance is 0.05347 μg. mL-1, the relative standard deviation does not exceed 0.1686% with a detection limit of 0.0552 μg mL-1 and a quantitative limit of 0.1674 μg.mL-1. The method has been successfully applied in the determination of dapsone in pharmaceutical tablets.

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Published

2024-06-30

How to Cite

Zaean , B. M., Humeidy , I. T., & Abdelaziz, M. S. (2024). Spectrophotometric determination of dapsone by oxidative coupling method using trifluoperazine hydrochloride reagent. Samarra Journal of Pure and Applied Science, 6(2), 17–32. https://doi.org/10.54153/sjpas.2024.v6i1.593

Issue

Vol. 6 No. 2 (2024): Samarra Journal of Pure and Applied Science

Section

Chemistry

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