Evaluation of the activity of alpha-glucosidase with some antioxidants in patients with type 2 diabetes

Abstract

The study included estimating the activity of alpha-glucosidase enzyme with some biochemical variables in the serum of type 2 diabetics. The study included 50 samples of patients with type 2 diabetes, whose ages ranged from 40-70 years, and 40 samples of healthy people of the same age group. The results showed that there was a significant decrease in the activity of alpha-glucosidase in patients compared to healthy subjects, as the average activity of alpha-glucosidase enzyme in patients was 42.7342 ± 4.5680 ng/ml compared to 117.4237 ± 10.0305 ng/ml in healthy subjects. The results also showed a significant increase in the level of fasting glucose concentration in the sera of patients, as it amounted to 25.0773 ± 252.8400 mg/dl, compared to healthy subjects, which amounted to 89.0250 ± 8.1224 mg/dl, As well as a significant decrease in the enzyme glutathione peroxidase in the group of patients, as its level in the patients' sera was 3.1723 ± 31.2400 ng/ml compared to healthy subjects 12.8036 ± 111.3580 ng/ml .While the level of glutathione in patients decreased by 14.5530 ± 1.3911 nmol/L compared to healthy subjects by 4.112 ± 43.9763 nmol/L, While the level of malondialdehyde increased in patients 4.2582 nmol/L 39.8000 ± compared to healthy subjects 1.5635± 14.4656 nmol/L.