Immunoglobulin –E (IgE) levels in patients with wounds infection caused by different bacterial species

Abstract

This study was designed to determine the immunoglobulin-E (IgE) levels in patients with wound infections caused by different bacterial species. Fifty fife samples were collected from patients suffering from wounds, including pus swabs and blood samples for both sexes, who attended Al- salam teaching Hospital and some outpatient clinics in Mosul City, with patients aged (8-50) years. During the time period of September 2022 to the end of March 2023. The data is entered into a questionnaire for the individuals that are the study's subject. To perform required laboratory tests, samples were sent to the lab.That detected (7.27%) include 4 patients were negative growth, and  (92.72%) include 51 patients were positive growth.(87.27%) of samples had only one species isolated from each sample, while (12.72%) include 7 patients were mixed cultures isolated from the total swabs. Staphylococcus aureus and Escherichia coli represented the highest rates among bacterial isolates at (33.33%)include 18 patients and (20.37%)include 11 patients respectively; pseudomonas aeroginosa and staphylococcus epidermidis were at (14.81%)inclued 8 patients, while a lower percentage of (10%) inclued 5 patients was for Klebsiella pneumonia. Antibiotic-resistant bacteria included isolates of Staphylococcus aureus, E. coli, Staphylococcus epidermidis, pseudomonas aeroginosa, and K. pneumoniae. Antibiotics included (Clindamycin (10 g/disc), Cefixime (5g/disc), Imipenem (10 g/disc), and Amoxicillin/Clavulanicacid (20/10 μg/disc). The largest percentage of gram-positive and gram-negative bacteria was in the age groups (21-30) years then (41–50) years, while the lowest percentage rate was in the age group (1–10) years. IgE showed the highest level (P≤0.05) reached at mean ±S.D (0.315±0.023ng/ml) with Pseudomonas aeroginosa infection and the lowest level (P≤0.135) at (0.141±0.072) with Staphylococcus epidermidies, compared with the control group where mean±S.D was(0.178±0.056).