Preparation and characterization of thiazines compounds derived from sulfamethoxazole, and evaluation of some of their antibacterial properties

Authors

  • Huda Turki Mahdi Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq
  • Malath Khalaf Rasheed Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq

DOI:

https://doi.org/10.54153/sjpas.2024.v6i2.625

Keywords:

2-Amino benzothiazol , thiazines,antibacterial, Sulfamethoxazole

Abstract

The 2-Aminobenzothiazol (A) was prepared by reacting Sulfamethoxazole with potassium thiocyanate in the presence of bromine as a catalyst. The Schiff’s base derivatives (H1-H3) were also prepared by reacting 2-Amino benzothiazol (A) with benzaldehyde derivatives in the presence of glacial acetic acid as a catalyst and ethanol as a solvent. Preparation of thiazines were derived from Schiff’s base derivatives (H1-H3) with the appropriate solvent. The effectiveness of some compounds against four types of bacteria (E. coli, S. aureus, S. pyogenes, K. pneumonia) was tested and the results showed that these prepared compounds have good to moderate activity against the bacteria used in the experiment at different concentrations (0.1, 1, and 10 mg/mL) compared to the standard antibiotic (Fluconazole) at a concentration of 5 mg/ml.

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Published

2024-06-30

How to Cite

Turki Mahdi, H., & Khalaf Rasheed, M. (2024). Preparation and characterization of thiazines compounds derived from sulfamethoxazole, and evaluation of some of their antibacterial properties. Samarra Journal of Pure and Applied Science, 6(2), 101–112. https://doi.org/10.54153/sjpas.2024.v6i2.625

Issue

Vol. 6 No. 2 (2024): Samarra Journal of Pure and Applied Science

Section

Chemistry

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