Spectrophotometric determination of meropenem trihydrate in pharmaceutical preparations by oxidative coupling reaction with mefenamic acid using sodium nitroprusside

Authors

  • Menaa AbdulSalam Al-Abbasi Department of Applied Chemistry, College of Applied Science, University of Samarra, Iraq
  • Eman Thiab Al Samarrai Department of Chemistry, College of Education, University of Samarra, Iraq
  • Liqaa Hussein Alwan Department of Chemistry, College of Education, University of Samarra, Iraq

DOI:

https://doi.org/10.54153/sjpas.2024.v6i2/2.663

Keywords:

Spectrophotometry, Oxidative Coupling, Meropenem, Mefenamic Acid, Sodium Nitroprusside.

Abstract

An accurate and rapid spectrophotometric method was developed for the determination of meropenem (Mer) in a basic aqueous medium at laboratory temperature, which depends on the oxidation of (Mer) with the oxidizing agent sodium nitroprusside (SNP) and conjugation of the oxidation product with mefenamic acid (MCF) and the formation of a complex with (yellow green) color،  And it gave the highest absorption at the wavelength of λmax 404 nm, with a linearity that ranged between 2-30 µg.ml-1 has a detection limit of 63.89×10-4µg.ml-1 has a value of 19.36×10-3 µg.ml-1 and the molar absorption coefficient is 14000.32 L.mol-1.CM-1 and the Sandall’s index of 0.03125 µg.cm-2 with a relative standard deviation not exceeding 0.8096% and a recovery between 99.0245 -100.8375%, which indicates the success of the proposed method in drug estimation in pharmaceutical preparations.

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Published

2024-08-30

How to Cite

Al-Abbasi, M. A., Al Samarrai , E. T., & Alwan , L. H. (2024). Spectrophotometric determination of meropenem trihydrate in pharmaceutical preparations by oxidative coupling reaction with mefenamic acid using sodium nitroprusside. Samarra Journal of Pure and Applied Science, 6(2(2), 85–99. https://doi.org/10.54153/sjpas.2024.v6i2/2.663

Issue

Vol. 6 No. 2(2) (2024): Samarra Journal of Pure and Applied Science

Section

Chemistry

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