Spectrophotometric determination of meropenem trihydrate in pharmaceutical preparations by oxidative coupling reaction with mefenamic acid using sodium nitroprusside
DOI:
https://doi.org/10.54153/sjpas.2024.v6i2/2.663Keywords:
Spectrophotometry, Oxidative Coupling, Meropenem, Mefenamic Acid, Sodium Nitroprusside.Abstract
An accurate and rapid spectrophotometric method was developed for the determination of meropenem (Mer) in a basic aqueous medium at laboratory temperature, which depends on the oxidation of (Mer) with the oxidizing agent sodium nitroprusside (SNP) and conjugation of the oxidation product with mefenamic acid (MCF) and the formation of a complex with (yellow green) color، And it gave the highest absorption at the wavelength of λmax 404 nm, with a linearity that ranged between 2-30 µg.ml-1 has a detection limit of 63.89×10-4µg.ml-1 has a value of 19.36×10-3 µg.ml-1 and the molar absorption coefficient is 14000.32 L.mol-1.CM-1 and the Sandall’s index of 0.03125 µg.cm-2 with a relative standard deviation not exceeding 0.8096% and a recovery between 99.0245 -100.8375%, which indicates the success of the proposed method in drug estimation in pharmaceutical preparations.
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