Synthesis, identification, and antibacterial activity screening of some 1H-tetrazol-5-amine derivatives

Authors

  • Mahmoud Hammadi Gailan Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq
  • Maha Salih Hussein Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq
  • Ghada F. Elmasry Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

DOI:

https://doi.org/10.54153/sjpas.2024.v6i1.674

Keywords:

Schiff bases, oxazepines, urea, thiourea, Mannich bases

Abstract

In this work, new compounds mj1-10 derived from 1H-tetrazol-5-amine and p-(dimethylamino) benzaldehyde moieties have been prepared through Schiff and Mannich reactions, which are well known for their medical importance. The chemical structures were confirmed spectrophotometrically using IR, 1H NMR, and 13C NMR spectra. The antibacterial activity of the newly synthesized compounds against Streptococcus mutans and Staphylococcus epidermidis was tested at different concentrations. It was found that the Mannich base 5mj achieved the highest inhibition efficacy compared to Tetracycline and Amikacin at 100 mg/ml. Accordingly, these candidates may serve as new scaffold to develop promising antibacterial agents in the future.

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Published

2024-03-30

How to Cite

Gailan, M. H., Hussein, M. S., & Elmasry, G. F. (2024). Synthesis, identification, and antibacterial activity screening of some 1H-tetrazol-5-amine derivatives. Samarra Journal of Pure and Applied Science, 6(1), 81–95. https://doi.org/10.54153/sjpas.2024.v6i1.674

Issue

Vol. 6 No. 1 (2024): Samarra Journal of Pure and Applied Science

Section

Chemistry

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