Preparation and Identification of Benzimidazole, and Benzothiazol Compounds Derived from (Gallic acid, Nicotinic acid) and Evaluation of the Antioxidant Activity of Some of Them
DOI:
https://doi.org/10.54153/sjpas.2024.v6i3.687Keywords:
Benzimidazole, Benzathiazole , Gallic acid , Nicotinic acid, AntioxidantsAbstract
The subject of the research includes the preparation of five-start heterocyclic compounds from (Gallic acid, Nicotinic acid). The compounds (C3, C4, C5, C6) was prepared by mixing equal molar amounts of (Gallic acid, Nicotinic acid) with the amino derivative (o-Phenylene diamine, 4- Methyl-o-Phenylene diamine. Benzthiazole (C10, C11) was prepared from glutathione with (2- Amino thiophenol), The prepared compounds were identified by physical properties such as melting point, color change, as well as spectral methods such as FT-IR,1H-NMR and Mass spectroscopy. The effectiveness of the compounds (Gallic acid, C3, C4, C10( Nicotinic acid,C6,C11) was estimated as antioxidants outside the body (in vitro) and by three methods, which are Reducing power assay, Scaveging of Hydrogen Peroxide, and Phosphomolybdenum Method, where some compounds showed high potential as antioxidants
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