Preparation and Identification of Benzimidazole, and Benzothiazol Compounds Derived from (Gallic acid, Nicotinic acid) and Evaluation of the Antioxidant Activity of Some of Them

Authors

  • Zainab Hashim Mohammed Department of Applied Chemistry, College of Applied Sciences, University of Samarra, Samarra, Iraq
  • Malath Khalaf Rasheed Department of Applied Chemistry, College of Applied Science, University of Samarra, Iraq
  • Rafah Razooq Hameed Al-Samarrai Department of Applied Chemistry, College of Applied Science, University of Samarra, Iraq

DOI:

https://doi.org/10.54153/sjpas.2024.v6i3.687

Keywords:

Benzimidazole, Benzathiazole , Gallic acid , Nicotinic acid, Antioxidants

Abstract

The subject of the research includes the preparation of five-start heterocyclic compounds from (Gallic acid, Nicotinic acid). The compounds (C3, C4, C5, C6) was prepared by mixing equal molar amounts of (Gallic acid, Nicotinic acid) with the amino derivative (o-Phenylene diamine, 4- Methyl-o-Phenylene diamine. Benzthiazole (C10, C11) was prepared from glutathione with (2- Amino thiophenol), The prepared compounds were identified by physical properties such as melting point, color change, as well as spectral methods such as FT-IR,1H-NMR and Mass spectroscopy. The effectiveness of the compounds (Gallic acid, C3, C4, C10( Nicotinic acid,C6,C11) was estimated as antioxidants outside the body (in vitro) and by three methods, which are Reducing power assay, Scaveging of Hydrogen Peroxide, and Phosphomolybdenum Method, where some compounds showed high potential as antioxidants

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Published

2024-09-30

How to Cite

Mohammed, Z. H., Khalaf Rasheed, M., & Razooq Hameed Al-Samarrai, R. (2024). Preparation and Identification of Benzimidazole, and Benzothiazol Compounds Derived from (Gallic acid, Nicotinic acid) and Evaluation of the Antioxidant Activity of Some of Them. Samarra Journal of Pure and Applied Science, 6(3), 56–71. https://doi.org/10.54153/sjpas.2024.v6i3.687