Study of the level of interleukin 6 in pregnant and aborted women and the histological changes associated with the placenta in the first trimester of pregnancy

Abstract

Miscarriage is a term that refers to the loss of a pregnancy before twenty weeks of the fetus’s lifespan, and this leads to complications and psychological problems for the woman who has an abortion. Studies are continuing to find out the reasons that lead to miscarriage, materials and methods of work. The study was conducted in the gynecology department and the maternity hall at Salah al-Din General Hospital, Tikrit city, Salah al-Din Governorate, for the period from October 2022 to March 2023. The study included 90 blood samples from women, including 20 samples for the control group and the same for the pregnancy group, and 50 blood samples for the miscarriage group, half of which were for the one-time miscarriage group and the other half for the recurrent miscarriage group. The histological study included 6 placental samples. 2 for the natural birth group, the same for the one-time abortion group, and the same for the recurrent miscarriage group. All of the women participating in the study did not suffer from chronic diseases such as high blood pressure and diabetes. The current study showed that the concentration of (IL-6) gave a high significant effect at the level (P ≤ 0.05), as the pregnancy, single-time miscarriage, and recurrent miscarriage groups each recorded a successive increase in the concentration of (IL-6) compared to the control group, and the histological study of the (Placenta) models recorded several results that led to the occurrence of miscarriage, the most important of which are coagulation, inflammation, and the proliferation of macrophages. Macrophage cells and giant autophagic cells. The study aimed to identify the causes of pregnancy failure and treat them, identify the effect of interleukin-6 level on pregnancy and miscarriage, and know the histological changes of the placenta after miscarriage during the first trimester of pregnancy.