An immunological study of acne patients using IgG3, TLR2 and IL-17A

Abstract

It was found after diagnosing 75 samples infected with acne that were collected from some health institutions in Salah-Din Governorate in the period between (8/2022 to 3/2023) and compared to the control group (15 healthy samples). Immunological tests were conducted using the ELIZA technology using three types of Antibodies: IgG3, TLR2, and IL-17A (serine-related cytotoxic T lymphocytes). The percentage of IgG3 formation in the immune system of infected samples reached (435.19971) g/ml. while the control group recorded (123.29864) g/ml. The highest recorded in the infected samples was (759.17642) g/ml, while the lowest in the infected samples was recorded (104.07295) g/ml, as for the immune receptor TLR2, it increased significantly, with a rate recorded at (792.07308) g/ml, and the highest infection recorded was (1237.73994) g/ml, while the lowest sample recorded was (154.92708) g/ml, compared to the control group, which recorded (133.46532) g /ml, while Interleukin IL-17A also recorded: a significant increase in the immune system of samples infected with acne. The rate of IL-17A in the affected samples was (43.29432) g/ml compared to the control group, so the rate of presence of IL-17A in blood serum was (26.51416) g/ml. The highest infection recorded was (55.47752) g/ml, while the least infected sample was recorded (12.6228) g/ml. It has also become clear from this study that the immune indicators IgG3, TLR2 and IL-17A are the best diagnostic indicators for people with acne than the immune indicators resulting from other infections. The study also proved that TLR2 is the most prominent immune indicator in people with acne.