Evaluation the effect of clove bud aqueous extract on asthma treatment

Authors

  • Bilal J M Aldahham department of Applied Chemistry, College of Applied Sciences-Heet, University of Anbar
  • Waleed Faraj Hamadi Al-Hiti department of Chemistry, College of Education for Women, University of Anbar
  • Omar Hamad Shehab Al-Obaidi department of Chemistry, College of Science, University of Anbar
  • Mohammed Oday Ezzat department of Chemistry, College of Education for Women, University of Anbar

DOI:

https://doi.org/10.54153/sjpas.2024.v6i1.909

Keywords:

Asthma, lipoxygenase, histidine decarboxylase, eugenol, OVA-induced

Abstract

The aim of this study is to find out how clove buds aqueous extract affected an ovalbumin (OVA)-induced allergic asthma model in mice used as an experimental model. After preparing the clove bud aqueous extract, it is examined as an enzyme inhibitor against 5-lipoxygenase and histidine decarboxylase. Then 30 mice divided into 5 groups to test the effective of clove extract in enhancing the situation of asthma by inhibiting the enzymes. The results showed that the concentration of 50 mg/kg/day gave significant differences versus OVA challenged group and generally using extract gave significant differences. As conclusion of this study we can say that the active constituent of clove extract may act as inhibitor of asthma main enzymes in a synergistic effect comparing of major constituent of extract "eugenol" in case of treating alone.

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Published

2024-04-01

How to Cite

M Aldahham, B. J., Faraj Hamadi Al-Hiti, W., Hamad Shehab Al-Obaidi, O., & Oday Ezzat, M. (2024). Evaluation the effect of clove bud aqueous extract on asthma treatment. Samarra Journal of Pure and Applied Science, 6(1), 277–288. https://doi.org/10.54153/sjpas.2024.v6i1.909

Issue

Vol. 6 No. 1 (2024): Samarra Journal of Pure and Applied Science

Section

Articles

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