Synthesis, characterization and antibacterial activity of some diacetamides derivatives

Abstract

 In this work,new compounds of derivatives were synthesised by using  traditionalmethod, wich was represented by adding  2 mole of the chloro acetayle  with1 mole of  various aromatic amines such as O-phenyle amine and 1,8-Naphthalene di amine, lin different conditions , The different basic basis was obtained for the first materials and then add mole to 2 mole of the ring-semicular ,such as  Morpholine, bipyridine, pyrazin ,pyridine and the reaction was monitored by using thin layer chromatography (TLC). All these compounds were investigated by the and were characterized by spectral methods such as infrared spectrum, (FTIR) proton nuclear magnetic resnance (¹H-NMR) and carbon 13 (¹³C-NMR). The antibacterial study was investigated by using two types of bacteria Escherichia coli[Gr-ve] and Staphylococcusaureus[Gr +ve]. The tetracycline and ciprofloxacin were used as a control in this study.