Prestin as a biomarker for early detection of sensorineural hearing loss

Abstract

To evaluate levels of the protein Prestin and its relationship to hearing loss limit, we conducted a cross-sectional study with 90 participants in Samarra, Iraq. Serum peristin levels were assessed using ELISA. Auditory function was assessed at frequencies from 0.125 to 8 kHz in a soundproof room. The participants were classified into three groups, the first group included healthy people, the second group patients with moderate hearing impairment, and the third group patients with severe hearing impairment. The results showed that there is an increase in the protein concentration whenever there is an increase in hearing loss, and that the levels of pristine concentration in the blood may reflect cochlear damage and thus serve as a biomarker for early, easily measurable sensorineural hearing loss.