Indirect Spectrophotometric Determination of Paracetamol by Bleaching of Dye Method with Potassium Permanganate as an Oxidation Reagent and Methyl Red Dye

Abstract

Paracetamol (Par) is determined by an indirect, simple, Economic method. This method is based on the reaction of access of Potassium Permanganate (PP) as an oxidation reagent with Par, the access of PP reacts with Methyl Red Dye (MR. When the Par concentration increases, the access of PP decreases, and the dye concentration which oxiadizes decreases, then the absorbance will increase with the increase of Par concentration. A number of conditions affecting on the reaction have been studied in order to reach the best results. The linearity was up to 0.4-1.1 µg/ml, the value of R² was 0.9983, molar absorptivity was 46525.06000 L/mol.cm, Sandell's index was 0.00334 µg/cm², and the limit of detection and limit of quantification were 0.01740 and 0,05220 µg/ml respectively. The method applied successfully to determination of Par in synthetic and Pharmaceutical forms.