Spectrophotometric Determination of Paracetamol, Ibuprofen, and Caffeine in Novafen Capsules by Vierordt's Method and Crammer's Rule for Dissolving the Trinomial Equations
DOI:
https://doi.org/10.54153/sjpas.2022.v4i1.346Keywords:
Spectrophotometric Determination,Paracetamol, Ibuprofen, Caffeine, Novafen, Vierordt, Crammer.Abstract
A Simple, Fast, and Economic Spectrophotometric method for the Determination of Par, Ibu, and Caf in their Synthetic and Pharmaceutical Mixtures. The method is a Vierordt's method (Simultaneous Equations) and Crammer's rule for dissolving the trinomial equations. The absorbance at maximum wavelength of these components were measured at 242, 222, and 274 nm respectively. The linearity of all calibration curves was 5-50 µg/ml except the calibration curve of Par at 274 nm was 15-50 µg/ml. The values of R2 were between 0.9973-0.9996. the accuracy and precision of the method were tested, The Rec% values were between 95.20138-104.79505% and RSD% values were between 0.85148-3.08486% within-day and 0.92810-2.88425% with-out day. The method was successfully applied for the determination of mentioned components in their synthetic and pharmaceutical mixtures.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Samarra Journal of Pure and Applied Science
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright Notice
Authors retain copyright and grant the SJPAS journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in Samarra Journal of Pure and Applied Science.
The Samarra Journal of Pure and Applied Science permits and encourages authors to archive Pre-print and Post-print items submitted to the journal on personal websites or institutional repositories per the author's choice while providing bibliographic details that credit their submission, and publication in this journal. This includes the archiving of a submitted version, an accepted version, or a published version without any Risks.
