Pharmacological efficacy of the antibiotic Meropenem of various origins against Pseudomonas aeruginosa isolated from wounds

Abstract

The study was conducted at the Faculty of Education-Samara University-Graduate Studies Laboratory, Department of life sciences and laboratories of the public company for Pharmaceutical Industries and medical supplies in Samara for the period from 3/9/2022 to 20/3/2023, where 37 samples were collected from people with wounds of both sexes (Samara General Hospital, some clinics) and diagnosed according to the phenotypic, culture and biochemical characteristics of the bacterium Pseudomonas aeruginosa, 30 isolates were obtained from them. The effectiveness of the antibiotic Meropenem was tested in the form of liquid needles for five different origins, of which different concentrations worked (0.001, 0.025, 0.05, 0.075, 0.10) the results of the statistical analysis showed that there were minor intestinal differences between the five origins, as for the average concentrations, it had a significant effect on inhibition, as the inhibitory effectiveness is directly proportional to the increase in concentration, where there were significant differences between the rates of inhibitory diameters, where the results showed that the effectiveness of the antibiotic Meropenem was high, where the antibiotic meropenem , Britain , France , Cyprus, Turkey) showed average concentrations with inhibitory diameters (40.1, 39.3, 37.4, 34.2, 30.0) mm in a row at concentrations (0.10 , 0.075 ,0.05 ,0.025 , 0.001) mg / mL.