Synthesis and Identification of Some New bi-azetidine 2,2ʹ- dione and bi-quinazoline-4,4 ʹ-dione Compounds derived from bis Schiff Base derivatives
DOI:
https://doi.org/10.54153/sjpas.2025.v7i2.994Keywords:
Heterocyclic compounds, Schiff bases, Azetidine, Quinazoline, biological activitiesAbstract
This research Included the preparation and characterization some derivatives Four and Six membered Heterocyclic Compounds (azetidine-2-one , quinazoline-4-one ). The first step inclode react benzaldehyde dervatives with hydrazine hydrate with appropriate glacial acetic acid in presence ethanol as solvent to get 1,2-bis(Substituted-benzylidene)hydrazine (A1-A7). The second step react (A1-A7) with (chloroacetylchloride) in the presence of triethylamine to get 4,4'-bis(substitutedphenyl)-3,3'-dichloro-[1,1'-biazetidine]-2,2'-dione (A8-A14), also react (A1-A7) with (2-amino benzoic acid) to get 2,2'-bis(substitutedphenyl)-1,1',2,2'-tetrahydro-4H,4'H-[3,3'-biquinazoline]-4,4'-dione (A15-A21). The prepared compounds were characterized by some physical properties and melting points in addition to (FT-IR), (1H-NMR), and (13C-NMR) by spectroscopic analysis.
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