Synthesis and Characterization of some new derivatives of thiadiazoles derived from ciprofloxacin Drug and Study of Their Biological Activity
Keywords:
Diazonium salt, Mannich Reaction, biological activity, Schiff base, TetrazoleAbstract
The first Schiff bases were designed in this study by reacting various aldehydes or ketones with thiadiazole derived from ciprofloxacin drug A glacial acetic acid role is a catalyst and caused the reaction to proceed faster (A1-A4). Subsequently, the Schiff bases react with Sodium azide in tetrahydrofuran as a solvent to prepared a new derivatives (A5-A8). Diazonium salt (A9) producing via diazotization with Acetyl acetone and Na2CO3to product (A10). Mannich reaction was performed to produce (A11-A16) via reaction of thiadiazole (A) with selected aldehyde and secondary amine. The prepared derivatives have been identified by FT-IR, 1HNMR Gram positive (Staphylococcus), Gram negative (Pseudomonas aeruginosa), and Fungi (Candida albicans) bacteria and fungi were successfully scanned by the antibacterial and antifungal action.
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