Synthesis and Characterization of some new derivatives of thiadiazoles derived from ciprofloxacin Drug and Study of Their Biological Activity

Authors

  • Jinan D. Ayash Medical City, Health Ministry, Baghdad
  • Sameaa J. Khammas Department of Chemistry, College of Science for Women, University of Baghdad

Keywords:

Diazonium salt, Mannich Reaction, biological activity, Schiff base, Tetrazole

Abstract

The first Schiff bases were designed in this study by reacting various aldehydes or ketones with thiadiazole derived from ciprofloxacin drug A glacial acetic acid role is a catalyst and caused the reaction to proceed faster (A1-A4). Subsequently, the Schiff bases react with Sodium azide  in tetrahydrofuran as a solvent  to prepared a new derivatives (A5-A8). Diazonium salt (A9) producing via diazotization with Acetyl acetone and Na2CO3to product (A10). Mannich reaction was performed to produce (A11-A16) via reaction of thiadiazole (A) with selected aldehyde and secondary amine. The prepared derivatives have been identified by FT-IR, 1HNMR Gram positive (Staphylococcus), Gram negative (Pseudomonas aeruginosa), and Fungi (Candida albicans) bacteria and fungi were successfully scanned by the antibacterial and antifungal action.

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Published

2024-12-30

How to Cite

D. Ayash, J., & J. Khammas, S. (2024). Synthesis and Characterization of some new derivatives of thiadiazoles derived from ciprofloxacin Drug and Study of Their Biological Activity . Samarra Journal of Pure and Applied Science, 6(4), 21–34. Retrieved from https://sjpas.com/index.php/sjpas/article/view/720

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