Synthesis, Spectral Characterization and Biological Activity of Schiff Base ligand Derived from 5-amino-2-phenyl-2,4-dihydro-3H-Pyrazol-3-one and its Metal Complexes
DOI:
https://doi.org/10.54153/sjpas.2025.v7i1.848Keywords:
Schiff Base, Metal Complexes, Biological Activity, Spectral Characterization, PyrazoloAbstract
Eight new complexes with the general formula [M(L)2(H2O)2] were prepared resulting from the reaction of the new Schiff base ligand [(E)-5-((2-hydroxybenzylidene)amino)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one(L)] with metal ions [manganese, cadmium, zinc, copper, nickel, cobalt, Mercury Bivalent and tetravalent platinum. This ligand was derived from the reaction of the amine (5-amino-2-phenyl-2,4-dihydro-3H-pyrazol-3-one) with Salicylaldehyde, which is linked to the metal ions via two atoms, the nitrogen is the isomethene group and the oxygen is the hydroxide group of the pyrazoline ring. The prepared compounds were characterized using infrared spectroscopy, nuclear magnetic resonance spectroscopy, and ultraviolet spectroscopy, and from the results of the measurements, the octahedral geometric of the prepared complexes were proposed. The inhibitory ability of the prepared compounds was tested against two types of selected bacteria: Staphylococcus aureus, Escherichia coli, and Candida fungi, which showed that the ability of the metal complexes to inhibit is higher than the ligand.
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