Study of Age, Body Mass Index, Stages of Colon Cancer Development, and Type of Treatment on Meprin Alpha Levels Among Colon Cancer Patients

Authors

  • Sukayna H. Rashed Department of Chemistry, College of Science, University of Mosul, Mosul
  • Luay A. Al-Helaly Department of chemistry, College of Science, Mosul University
  • Firas T. Maher Department of Chemistry, College of Science, University of Tikrit

DOI:

https://doi.org/10.54153/sjpas.2021.v3i4.305

Keywords:

Meprin Alpha, Stage, Treatment, BMI, Colon cancer

Abstract

Colon cancer is a disease that is characterized by the development of malignant cells in the epithelium or lining of the distal part of the colon. This study includes study of age, body mass index, stages of colon cancer development, and quality of treatment on meprin α (MEPA) levels among colon cancer patients as compared with the control group. This study has been conducted on (134) sample with ages ranging from (25-76) years: (74) of them are colon cancer patients from the patients treated in Mosul oncology and nuclear medicine hospital and Ibn-Sina teaching hospital/ Mosul and (60) samples as control group in Mosul city for the period from January to July 2020. The results showed that the normal mean of MEPA is (82.12± 3.65 ng / mL) in control group for both gender. While the activity of MEPA for colon cancer patients were (106.72±4.52 ng / mL), the level of enzyme was also affected by age and gender, whereas it increases with age in both the control group and colon cancer patients, its activity in males is higher than in females in control group only, and the effect of body mass index is observed in both the control group and the patients.  The results also showed a significant increase in the activity of MEPA in colon cancer patients as compared with the control group, while there was a significant increase in colon cancer patients in stages II, III and IV compared with patients in the first stage. The effect of the type of treatment, as it has been found that the activity of enzyme was significantly lower for MEPA in the group of patients undergoing surgical removal of colon tumors and patients treated with chemotherapy as compared without treatment patients (Newly diagnosed). It was noted that MEPA is affected by various factors such as gender, age, BMI, as well as the development of colon cancer and the type of treatment used.

The results showed that the normal mean of MEPA is (82.12± 3.65 ng / mL) in control group for both sexes. While the activity of MEPA for colon cancer patients were (106.72±4.52 ng / mL), the level of enzyme was also affected by age and sex, whereas it increases with age in both the control group and colon cancer patients, its activity in males is higher than in females in control group only, and the effect of body mass index is observed in both the control group and the patients.

The results also showed a significant increase in the activity of MEPA in colon cancer patients as compared with the control group, while there was a significant increase in colon cancer patients in stages II, III and IV  compared with patients in the first stage

The effect of the type of treatment, as it has been found that the activity of enzyme was significantly lower for MEPA in the group of patients undergoing surgical removal of colon tumors and patients treated with chemotherapy as compared without treatment patients.

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Published

2021-12-30