Synthesis of new 1,3,4-oxadiazole derivatives from indomethacin acid and evaluation of their biological activity

Authors

  • Nora Amer Hussein Department of Chemistry, College of Science, University of Mosul, Iraq
  • Hayfaa Younis Hussien Department of Chemistry, College of Science, University of Mosul, Iraq
  • Shaymaa Hashim Abdulrahman Department of Chemistry, College of Science, University of Mosul, Iraq.

DOI:

https://doi.org/10.54153/sjpas.2024.v6i2/2.670

Keywords:

Indomethacin, Oxadizole, Biologic Activity, NMR, IR

Abstract

The research included the synthesis of 5-amino-1,3,4-oxadiazole-2-yl by reacting indomethacin acid with semicarbazide hydrochloride, using phosphorus oxychloride e (POCl3) as a cyclizing agent, with the help of potassium hydroxide, and then reacting 5-amino-1,3,4- Oxadiazole-2-yl with aldehydes to obtain new and different types of Schiff bases. The biological activity of the prepared compounds against E-coli bacteria was studied. The structures of the newly prepared compounds were characterized using physical methods and measuring H1-NMR and IR spectra.

Published

2024-08-30

How to Cite

Hussein, N. A., Hussien, H. Y., & Abdulrahman, S. H. (2024). Synthesis of new 1,3,4-oxadiazole derivatives from indomethacin acid and evaluation of their biological activity. Samarra Journal of Pure and Applied Science, 6(2(2), 100–109. https://doi.org/10.54153/sjpas.2024.v6i2/2.670