Synthesis of new 1,3,4-oxadiazole derivatives from indomethacin acid and evaluation of their biological activity

Authors

  • Nora Amer Hussein Department of Chemistry, College of Science, University of Mosul, Iraq
  • Hayfaa Younis Hussien Department of Chemistry, College of Science, University of Mosul, Iraq
  • Shaymaa Hashim Abdulrahman Department of Chemistry, College of Science, University of Mosul, Iraq.

DOI:

https://doi.org/10.54153/sjpas.2024.v6i2/2.670

Keywords:

Indomethacin, Oxadizole, Biologic Activity, NMR, IR

Abstract

The research included the synthesis of 5-amino-1,3,4-oxadiazole-2-yl by reacting indomethacin acid with semicarbazide hydrochloride, using phosphorus oxychloride e (POCl3) as a cyclizing agent, with the help of potassium hydroxide, and then reacting 5-amino-1,3,4- Oxadiazole-2-yl with aldehydes to obtain new and different types of Schiff bases. The biological activity of the prepared compounds against E-coli bacteria was studied. The structures of the newly prepared compounds were characterized using physical methods and measuring H1-NMR and IR spectra.

Downloads

Published

2024-08-30

How to Cite

Hussein, N. A., Hussien, H. Y., & Abdulrahman, S. H. (2024). Synthesis of new 1,3,4-oxadiazole derivatives from indomethacin acid and evaluation of their biological activity. Samarra Journal of Pure and Applied Science, 6(2(2), 100–109. https://doi.org/10.54153/sjpas.2024.v6i2/2.670

Issue

Vol. 6 No. 2(2) (2024): Samarra Journal of Pure and Applied Science

Section

Chemistry

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright Notice

Authors retain copyright and grant the SJPAS journal right of first publication, with the work simultaneously licensed under a  Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in Samarra Journal of Pure and Applied Science.

The Samarra Journal of Pure and Applied Science permits and encourages authors to archive Pre-print and Post-print items submitted to the journal on personal websites or institutional repositories per the author's choice while providing bibliographic details that credit their submission, and publication in this journal. This includes the archiving of a submitted version, an accepted version, or a published version without any Risks.