Study of Procollagen-lysine 5-dioxygenase and some biochemical parameters in coronary artery disease patients

Abstract

Cardiovascular diseases, specifically coronary artery disease, is among the most common causes of death at all ages and in both sexes, with coronary artery disease accounting for more than 40% of deaths attributable to cardiovascular disease. This clinical study included 160 individuals (80 males aged 35-75 years) with coronary artery disease and (80 of healthy males aged 35-67). The activity of procollagen-lysine 5-dioxygenase, renin, angiotensin-converting enzyme, and glutathione peroxidase were determined, in addition to the levels of glutathione, vitamin C, iron, glucose, malondialdehyde and C-reactive protein, in blood serum using ELISA kits and spectrophotometric method. The results showed a significant decrease in the activity of procollagen-lysine 5-dioxygenase, angiotensin-converting enzyme, and glutathione peroxidase, but a nonsignificant decrease in the activity of renin. As well as a significant decrease in the level of glutathione, vitamin-C and iron. On the other hand, the levels of glucose, malondialdehyde, and C-reactive protein were significantly increased in the patient group compared with the control group.