The sensitivity of heparin-binding growth factor as a diagnostic marker for atherosclerosis

Authors

  • Sara Emad Abd Alwahed Department of Pathological Analysis, College of Applied Science, University of Samarra
  • Rafah Razooq Hameed Al-Samarrai Department of Applied Chemistry, College of Applied Science, University of Samarra

Abstract

The study aimed to evaluate the level of heparin-binding growth factor (HBGF) as a sensitive ,arker for atherosclerosis.  study included collecting 90 serum samples (60 samples for patients with atherosclerosis and 30 samples from healthy individuals as a control group) to evaluate the level of HBGF, calcium, and lipid profile in patients with atherosclerosis. The patients samples were collected from the Ibn Al-Bitar Cardiac Surgery Center in Baghdad Governorate for the period from 1/11/2023 to 1/1/2024. The levels of HBGF, calcium, and lipid profile'[total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)}. The results showed a significant increase in the levels of HBGF, TC, TG, LDL-C and calcium, with a significant decrease in HDL-C level in the patient s group as compared to the control.Receiver-operating characteristic curve analysis showed that the AUC for the HBGF is outstanding, with excellent sensitivity, in addition to the excellent accuracy for cholesterol LDL-C and HDL-C in the diagnosis of the disease. From the results, we can conclude that  HBGF is a sensitive parameter for diagnosing atherosclerosis with a high sensitivity.

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Published

2024-10-01

How to Cite

Abd Alwahed, S. E., & Al-Samarrai, R. R. H. (2024). The sensitivity of heparin-binding growth factor as a diagnostic marker for atherosclerosis. Samarra Journal of Pure and Applied Science, 6(3(2), 140–153. Retrieved from https://sjpas.com/index.php/sjpas/article/view/941

Issue

Vol. 6 No. 3(2) (2024): The second International Conference for Pure and Applied Sciences (2SICPS)-2024

Section

Biology

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