Hypolipidemic and antioxidant effect of liposomal Rosuvastatin in vivo
DOI:
https://doi.org/10.54153/sjpas.2024.v6i3(2).860Keywords:
Rosuvastatin, Liposome, Zeta Potential, β-sitosterol, Scanning Electron Microscopy and peroxisome proliferator-activated receptor gamma.Abstract
Liposomes are special kinds of lipid vesicles with phospholipid complexes and amphiphilicity. They can help the body use and absorb drugs that don't dissolve well in water. The objective of the current study is to increase the bioavailability and solubility of rosuvastatin calcium (ROSCa) in aqueous media.Liposomal rosuvastatin was synthesized after decalcification (dicalcium) to complete phospholipid binding. Optical microscopy(Safranin, methyl blue and methyl red ) Scanning Electron Microscopy ,zeta potential during month, Along with their electrophoretic mobility, viscosity and charge mobility were used to characterize the formation of liposomes, in vivo effect of the liposome on the level of lipid profile, Hydroxy methyl glutaral-Co reductase and peroxisome proliferator-activated receptor gamma compared to the rosuvastatin calcium and to know the ability of the prepared liposome to raise antioxidants or fight free radicals resulting from feeding a high-cholesterol diet.The study's findings show that the prepared liposome by SEM results showed that the vesicle size was 37.99-75.77 nm and Small single fat vesicles surrounded by an aqueous layer, and has a zeta potential was -50.54 the drug was found to be stable ,The charge of the liposome, electrophoretic mobility, and viscosity were -0.0007, 3.95 µm/cm.sec.V., and 0.714x10-3±0.007 poise, respectively. ,in vivo results liposome reduced the concentration of T.Ch, T.G and LDL and improved the level of HDL and HMG-CoA compared to rosuvastatin calcium as for its ability to resist harmful oxidation, its effect on malondialdehyde and peroxy nitrate decreased compared to Rosuvastatin calcium It also It also improved the levels of total antioxidants and R-SH .From all the results, we can conclude that the liposomal drug showed hypocholesterolemic and oxidative stress efficiency, which may be due to the improvement of the bioavailability of the drug in the liposomal formula.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Notice
Authors retain copyright and grant the SJPAS journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in Samarra Journal of Pure and Applied Science.
The Samarra Journal of Pure and Applied Science permits and encourages authors to archive Pre-print and Post-print items submitted to the journal on personal websites or institutional repositories per the author's choice while providing bibliographic details that credit their submission, and publication in this journal. This includes the archiving of a submitted version, an accepted version, or a published version without any Risks.