The role of kynurenine and tenascin C in Iraqi patients with type 2 diabetes

Abstract

Kynurenines show a great many natural activities (which are frequently differentiating, for example, cytotoxic/cytoprotective, oxidant/cell reinforcement or supportive of/mitigating. The net impact relies upon their nearby fixation, cell climate, as well as intricate positive and negative criticism circles. The awkwardness among gainful and unsafe kynurenines was ensnared in the pathogenesis of different neurodegenerative problems, mental ailments and metabolic issues, including diabetes mellitus. The aim of this study is to know the effect of diabetes on both Kynurenine and Tenascin C when compared to healthy people and vice versa. A study was conducted on 60 individuals aged 35-50 years, including 20 healthy individuals, and 40 individuals with chronic diabetes. Lipid profile, Uric acid, Urea, Creatinine were measured by spectrophotometer. While HbA1c was measured by iChroma. Insulin test uses a sandwich immunodetection method, while kynurenine. tenascin c by Elisa kits. The results showed Significant differences (P ≤ 0.001) between the studied groups and healthy individuals, as we note an increase in both Kynurenine and Tenascin c in patients. Conclusion Kynurenine and tensin-C may be a good biomarker for the diagnosis of diabetes.