Evaluation copeptin and some biochemical parameters in type 2 diabetic patients in Samarra city

Abstract

The study included evaluation of copeptin level and some biochemical parameters in sera of type 2 diabetes patients. The study included 50 samples of type 2 diabetes patients, as well as 40 of blood samples of apperently healthy individuals as control with ages ranged between 40-70 years old for two groups. The results showed a significant increase at (p≤0.01) in copeptin level of patients (625.741±96.181pg/ml) compared with control (382.115±81.718pg/ml). Glucose level showed a significant increase at (p ≤0.01) in patients group (228.86±60.436 mg/dl) compared with control (96.68±12.294 mg/dl). The results also indicates a significant increase at (p ≤0.01) in cholesterol and Triglycerides and significant decrease in High Density lipoprotein and significant increase in very low Density lipoprotein and low Density lipoprotein lipoprotein levels (207.705±35.338 and 209.984±30.414 and 37.242±4.134 and 41.997±6.082 and 128.466±37.019  mg/dl) respectively in patients compared with control (192.345±11.381 and 146.948±23.680 and 61.668±6.391 and 29.389±4.736 and 101.287±13.824 mg/dl) respectively. The level of glutathione decreased at (p ≤0.01) significantly in sera of diabetes patients (5.856±0.591μmol/l) compared with control (10.121±0.500μmol/l), while malondialdehyde level was increased significantly (24.116±12.964μmol/l) in patients compared with control (14.058±5.596μmol/l).