Evaluation of Fetuin A and some biochemical indicators in people with type 2 diabetes

Abstract

Diabetes is a clinical disease characterized by high blood sugar. This is caused by a deficiency or absence of insulin secretion by the pancreas. The progression of diabetes can lead to serious complications that may affect the heart, arteries, and kidneys. Fetuin A is a glycoprotein secreted by the liver that promotes insulin resistance by inhibiting insulin receptor tyrosine kinase in the liver and skeletal muscle. It plays important roles in the body, particularly in regulating metabolism, inflammation, and tissue calcification. Fetuin A is strongly associated with insulin resistance and, consequently, the development of type 2 diabetes. The study included collecting 90 samples from patients at Samarra General Hospital, 60 samples with type 2 diabetes and 30 healthy people as a control group, their ages ranged between (35-65) years, in the period between 22-9-2024 until 22-11-2024, and the results of the study showed a significant increase at the probability level (P<0.05) in the level of fetuin A in the group of patients with type 2 diabetes compared to healthy people. The study also showed a significant increase in glucose levels in patients compared to healthy individuals. The study results also showed an increase in creatinine and uric acid levels in patients with type 2 diabetes compared to healthy individuals. As for urea, there was no significant difference at the probability level (P<0.05) between the two groups of patients with type 2 diabetes and the healthy group. The results also showed an increase in the levels of cholesterol, triglycerides, low-density lipoproteins, and very low-density lipoproteins, and a decrease in the level of high-density lipoproteins in patients compared to healthy individuals.