Quercetin Isolated from Allium cepa Mitigates Hepatic Oxidative Stress and Preserves Liver Function in Rabbits: Biochemical, Antioxidant, and Histopathological Evidence
DOI:
https://doi.org/10.54153/sjpas.2026.v8i2.1438Keywords:
Quercetin, Hepatoprotection Oxidative Stress, Allium cepa, Antioxidant DefenseAbstract
This study evaluated the effects of quercetin isolated from Allium cepa on hepatic oxidative stress and liver function in rabbits. Adult male New Zealand White rabbits were randomly allocated into four groups (n = 10): control, quercetin (50 mg/kg), quercetin (100 mg/kg), and silymarin (100 mg/kg) as a positive control. Treatments were administered orally for 28 days. Serum liver enzymes (ALT, AST), hepatic oxidative stress markers (MDA, SOD, CAT, GSH), and liver histopathology were assessed. Quercetin significantly reduced ALT and AST activities and decreased hepatic MDA levels, while increasing SOD, CAT, and GSH in a dose-dependent manner (p < 0.05). Histopathological examination demonstrated improved liver architecture with reduced degeneration, inflammation, and steatosis, particularly at 100 mg/kg. The effects were comparable to silymarin. These findings indicate that quercetin exerts antioxidant and hepatoprotective effects in rabbits and may support liver health.
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