The influence of hydroxychloroquine on the histological and physiological structure of the kidneys and the preventive role of caraway in female albino rats

Abstract

The Current study was Conducted in the animal house and Laboratories of the college of Veterinary Medicine, Tikrit University, starting from the date of (12/10/2023) to (11/11/2023). it Aimed to evaluation of the role of the drug hydroxy chloroquine in causing histological and physiological changes in the kidneys, and the therapeutic role of the caraway plant and its preventive effect in female white rats. It was distributed into 6 groups for 5 animals for each.  A Group: the first group, including the control group, was fed a regular diet and water throughout the experiment. The second group was dosed with the therapeutic dose of hydroxyl chloroquine at a concentration of 0.3mg/kg for30 days. The third group was dosed with the supra-therapeutic dose of hydroxyl chloroquine. The fourth group was dosed with caraway extract at a concentration of 60mg/kg for 30mg. The fifth group was doses the hydroxychloroquine with caraway extract to (30) days.  The sixth group was dosed with the supra-therapeutic dose of hydroxyl chloroquine at a concentration of 0.6 mg/kg and caraway extracts for 30 days. After the end of the experiment, the animals were anesthetized and blood was drawn directly from the heart, and these physiological tests of kidney function were performed from blood serum. The results of microscopic examination of histological sections of the kidneys showed thickening of Bowman's capsule, necrosis, and blood congestion.