Synthesis, structural and Anti-Bacterial Study of Mn(II), Co(II), Zn(II), and Hg(II) Complexes with New Ligand 4-nitro-N-(pyrimidin-2-ylcarbamothioyl) benzamide
DOI:
https://doi.org/10.54153/sjpas.2025.v7i2.1068Keywords:
4-nitrobenzoyl isothiocyanate, Antimicrobial activity, Escherichia coli, 4-nitrobenzoyl IsothiocyanateAbstract
Using a 2-Amino pyrimidine and 4-nitrobenzoyl isothiocyanate , a novel ligand 4-nitro-N - (pyrimidin-2-ylcarbamothioyl) benzamide (L') has been created. A few of the ligand's transition metal complexes have been designed and described using the UV-vis spectra, FT-IR, magnetic susceptibilities, conductivity measurements, and atomic absorptions. The ligand was identified using C.H.N.S., UV-Vis, FT-IR, and 1 H, 13 CNMR spectra. The behavior of the ligand is comparable to that of a bidentate coordinating through atoms S and O. According to the data, the chemical formula of every complex created was [M(L)2Cl2] (M (II) = Mn, Co, Zn and Hg). An octahedral geometrical structure was proposed for each complex. Escherichia coli and Staphylococcus aureus are two microorganisms that the metal and ligand complexes show good activity against.
References
Jaafar, W.A. (2018). Synthesis , Structural Study and Biological Activity Evaluation of Cr (III), Mn (II), Zn (II), Cd (II) and Hg (II) Complexes with New Schiff Base Ligand Derived from Isatin. Journal of Global Pharma Technology ,10(06), 513-520.
2. Hassan, S. A. (2022). Synthesis and characterization of mixed ligand complexes from curcumin and new schiff base derived from isatin for some metallic ions and evaluation biological activities. Research Journal of Pharmacy and Technology, 15(4), 1537-1542.
3. Jaafar, W. A., Fezea, S. M., & Al-Shemary, R. K. R. (2018). Employing the physicochemical, spectroscopy, antimicrobial and antifungal efficacy studies of p-hydroxy acetophenone based azo schiff base complexes. Journal of Global Pharma Technology,10(6),503–12.
4. Hassan, S. A., & Hassan, W. F. (2022). Structural and Spectral studies of new mixed Ligand complexes for 2-Amino-4-nitrophenol with some Metallic ions and Evaluation their Biological Activities. Research Journal of Pharmacy and Technology, 15(8), 3634-3640.
5. Lateef, S. M., Sarhan, B. M., & Al-Saedi, W. A. (2016). Synthesis, Characterization and Biological Activity for Complexes VO (II), Mn (II), Co (II) and Ni (II) with new multidentate ligand [2-((E)-3-(2-hydroxyphenylimino)-1, 5-dimethyl-2-phenyl-2, 3-dihydro-1H-pyrazol-4-ylimino) acetic acid][H2L] type (N2). Diyala Journal for pure Sciences, 12(1), 10-27.
6. Alwan, T. B., & Hassan, S. A. (2023). Thermodynamic Studies Of Cu (II) complex of new bidentate Schiff base ligand type (NO) derived from Mebendazol. Egyptian Journal of Chemistry, 66(1), 563-572.
7. Al-Saedi, W. A. J. (2012). Synthesis, Characterisation and biological activity for binuclear complexes with Co (II), Cu (II) and Zn (II) with new ligand m-phenylendi (azo-2-naphthol) ligand type N2O2. Ibn AL-Haitham Journal For Pure and Applied Sciences, 25(1).
8. Hassan, S. A., Lateef, S. M., & Majeed, I. Y. (2018). Structural, Spectral and Thermal Studies of New Bidentate Schiff Base Ligand Type (NN) Derived from Mebendazol and 2-Aminobenzothaizol and its Metal Complexes and Evaluation of their Biological Activity. Journal of Global Pharma Technology, 10(07), 307-317.
9. Hasan, H. A., Samir, A. H., & Al-Saedi, W. A. J. (2011). Specroscopic and Biological Activity Studies of Thiadiazole Ligand Type N2O and its Complexes with Fe (II), Co (II) and Ni (II). Al-Mustansiriyah Journal of Science, 22(4), 222–32.
10. Abd Alkareem, T., Hassan, S., & Abdalhadi, S. (2023). Breast cancer: symptoms, causes, and treatment by metal complexes: a review. Advanced Journal of Chemistry-Section B: Natural Products and Medical Chemistry, 5(4), 306-319.
11. Ibrahim, O. B., Mohamed, M. A., & Refat, M. S. (2014). Nano sized schiff base complexes with Mn (II), Co (II), Cu (II), Ni (II) and Zn (II) metals: synthesis, spectroscopic and medicinal studies. Canadian Chemical Transactions, 2(2), 108-121.
12. Raman, N., Kulandaisamy, A., & Jeyasubramanian, K. (2002). Synthesis, spectral, redox and biological studies of some Schiff base copper (II), nickel (II), cobalt (II), manganese (II), zinc (II) and oxovanadium (II) complexes derived from 1-phenyl-2, 3-dimethyl-4 (4-iminopentan-2-one) pyrazol-5-one and 2-aminophenol/2-aminothiophenol,Indian Journal of Chemistry, 14A,942-494.
13. Salloom, H. K., Lateef, S. M., & Hassan, S. A. (2020). Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms Derived from Nalidixic Acid and 4-Aminoantipyrine and Metal Complexes and Evaluation of their Biological Activity. Journal of Global Pharma Technology, 12(2), 26-36.
14. Abhay, N. S., Netra, P. S., & Chand, K. S. (2016). In vitro antibacterial and antifungal activities of binuclear transition metal complexes of ONNO Schiff base and 5-methyl-2,6-pyrimidine-dione and their spectroscopic validation , Arabian Journal of Chemistry, 9(1) 48-61.
15. Fayyadh, B.M., Jaafar,W.A., Sarhan, B.M. (2021). Synthesis, Structural Study and Biological Activity Evaluationof VO(II), Mn(II), Co(II),Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) Complexes with New Schiff Base Ligand Derived from Pyrazine, International Journal of Drug Delivery Technology,11(1),1-6.
16. Hayes, K.F., Katz, L.E. (2020). Chapter:Application of X-ray absorption spectroscopy for surface complexation modeling of metal ion sorption, Book:Physics and chemistry of mineral surfaces 147-223.
17. Hassan, S. A., & Lateef, S. M. (2021). Synthesis, structural, thermal and biological studies for new Schiff base derived from Isoniazid and it's complexes with metal ions. Egyptian Journal of Chemistry, 64(7), 3235-3243.
18. El-Sonbati, A. Z., Diab, M. A., El-Bindary, A. A., Abou-Dobara, M. I., & Seyam, H. A. (2013). Supramolecular coordination and antimicrobial activities of constructed mixed ligand complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 104, 213-221.
19. Singh, D. P., Malik, V., Kumar, R., & Kumar, K. (2010). Template synthesis of macrocyclic complexes of Co (II), Ni (II), Cu (II), Zn (II) and Cd (II): spectroscopic, antibacterial and antifungal studies. Journal of the Serbian Chemical Society, 75(6), 763-772.
20. El-Asmy, A. A., Al-Ansi, T. Y., & Shaibi, Y. M. (1989). Chelated complexes of cadmium (II), cobalt (II), copper (II), mercury (II), nickel (II), uranyl (II) and zinc (II) with benzil bis (4-phenylthiosemicarbazone). Transition Metal Chemistry, 14, 446-448.
21. Suresh, M. S., & Prakash, V. (2011). Preparation Characterization and Antibacterial Studies of Chelates of Schiff Base Derived from4‐Aminoantipyrine, Furfural and o‐phenylenediamine. Journal of Chemistry, 8(3), 1408-1416.
22. Suresh, M. S., & Prakash, V. (2011). Preparation Characterization and Antibacterial Studies of Chelates of Schiff Base Derived from4‐Aminoantipyrine, Furfural and o‐phenylenediamine. Journal of Chemistry, 8(3), 1408-1416.
23. Kavitha, T. H., Kulandaisamy, A. N. & Thillaiarasu, P. O. (2013). Synthesis, Spectroscopic Characterization, Electrochemical and Antimicrobial Studies of Copper (II), Nickel (II), Cobalt (II) and Zinc (II) Complexes Derived from 1-Phenyl-2, 3-dimethyl-4 (2-iminomethylbenzylidene)-pyrozol-5-(α-imino)-indole-3-propionic Acid. Trans, 2, S25-S32.
24. Mishra, A. P., Mishra, R., Jain, R., & Gupta, S. (2012). Synthesis of new VO (II), Co (II), Ni (II) and Cu (II) complexes with isatin-3-chloro-4-floroaniline and 2-pyridinecarboxylidene-4-aminoantipyrine and their antimicrobial studies. Mycobiology, 40(1), 20-26.
25. Fayyadh, B. M., Abd, N. A. B., & Sarhan, B. M. (2022, May). Synthesis and characterization of new Mn (II), Co (II), Cd (II) and Hg (II) complexes with ligand [N-(pyrimidin-2-ylcarbamothioyl) benzamide] and their anti-bacterial study. In IOP Conference Series: Earth and Environmental Science (Vol. 1029, No. 1, p. 012030).
26. P Pallai, D. B., Badekar, R. R., Momin, K. I., Bondge, A. S., Nagargoje, G. R., Kadam, P. D., ... & More, V. S. (2024). Synthesis, Spectral and Biological Studies of Co (II), Fe (II), Ni (II), Cu (II), Pd (II), Mn (II), Hg (II), Cd (II), and Zn (II) Complexes Derived from Benzohydrazide Schiff Base.
27. Jaafar, W. A., Fayyadh, B. M., AL-Musawi, D. K. R., & Sarhan, B. M. (2022). Structural, characterization and biological activity of new ligand N-(pyrimidin-2-yl carbamothioyl) acetamide and its complexes with (VO (II), Mn (II), Cu (II), Zn (II), Cd (II) and Hg (II). Egyptian Journal of Chemistry, 65(131), 1527-1531.
28. rasheed M. k., shaker M. A. & Al-Saedi, W. A. (2016). S Synthesis, Characterization, Biological Activity and Thermal Study of New Complexes [Ni II, Hg II and La III] from Mixed Ligands (Curcumin and Azo compounds type N2O2). Journal of Drug Delivery Technology, 13(3), 1024-1029.
29. Hassan, S. A., Lateef, S. M., & Majeed, I. Y. (2020). Structural, Spectral and Thermal studies of new bidentate Schiff base ligand type (NO) derived from Mebendazol and 4-Aminoantipyrine and it's metal complexes and evaluation of their biological activity. Research Journal of Pharmacy and Technology, 13(6), 3001-3006.
30. Alwan, T. B., Rajab, M. A., & Hassan, S. A. (2022). The effect of nanoparticle and fiber reinforcement on composites used in some applications of internal combustion engine parts. Egyptian Journal of Chemistry, 65(132), 411-416.
31. Patel, A., Bari, S., Talele, G., Patel, J., & Sarangapani, M. (2006). Synthesis and antimicrobial activity of some new isatin derivatives,5(4),249-254.
32. Ayati, A., Emami, S., Moghimi, S., & Foroumadi, A. (2019). Thiazole in the targeted anticancer drug discovery. Future medicinal chemistry, 11(15), 1929-1952.
33. Al-Kareem, A., Ahmed, T., Hassan, S. A., & Abdalhadi, S. M. (2024). Polycystic Ovary Syndrome: pathogenesis, management, and treatment with metals and organic compounds. Cellular, Molecular and Biomedical Reports, 4(1), 54-64.
34. Vale, N., Gomes, P., & A. Santos, H. (2013). Metabolism of the antituberculosis drug ethionamide. Current drug metabolism, 14(1), 151-158.
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