Evaluation levels some of hematological variable and biochemical and resistine hormone and body mass index for patients of chronic renal failure

Abstract

The study included evaluation level of some hematological variable such as PCV،PLT،WBC in the blood، and some biochemical variable such as urea and creatinine ،and resistine hormone in the blood serum، and calculate body mass index in studies groups. A total of 90 blood samples were collected and divided into two groups: a control group comprising 20 samples and a chronic renal failure group comprising 70 samples، with participants' ages ranging from 20 to 70 years. The sampling period extended from December 1، 2023، to April 28، 2024. The results demonstrated a statistically significant increase `in the levels of platelets (PLT)، white blood cells (WBC)، urea، creatinine، and resistin in the serum of the chronic renal failure group compared to the control group، with a probability threshold of P≤0. 05.. In contrast، a significant decrease was observed in the packed cell volume (PCV) and body mass index in the patient group relative to the control group. We conclude from this that the low level of PCV in patients of chronic renal failure because the hormone erythropoietin which controls the production of red blood cells is produced in the kidney and low PLT level occur as a result of bleeding that occur during the dialysis process، while high level of WBC are due to increased inflammatory conditions in chronic kidney disease. The reason for the high level of each of urea ، creatinin، and resistine hormone in patients of chronic renal failure be caused loss of kidney's excretory، metabolic، and hormonal effectiveness due to the continuous destruction of rental units (nephrons) and decrease in glomerular filtration rate، while low level of body mass index occurs due to weakness of nutrition state for patients.