The effect of Euphorbia milii and Sansevieria trifasciata plant extracts with antibiotics against Streptococcus pyogenes bacteria
DOI:
https://doi.org/10.54153/sjpas.2025.v7i4.1146Keywords:
Streptococcus pyogenes, Euphorbia milii, Sansevieriatrifasciata, synergisticAbstract
The study aimed to evaluate the antibacterial activity of both Euphorbia milii and Sansevieria trifasciata plant extracts and their synergistic effect with antibiotics against Streptococcus pyogenes. A total of 100 samples were collected from patient with tonsillitis, where 10 bacterial isolates of the target species were identified using chemical tests and PCR technique. The plant extracts were prepared using 70% ethanol, and their effect on bacteria was tested at different concentrations (25%,50%,75%,100%). The results showed that Euphorbia milii extract was more effective, with an average diameter of the inhibition zone of 18.8 mm at 100% concentration, compared to 14.6 mm for Sansevieriatrifasciata extract. When the extracts were combined with antibiotics Azithromycin(15mg), Tetracycline(10mg), Vancomycin (30), Clindamycin (10), a significant synergistic effect was observed, especially with azithromycin. The study showed that low concentrations of the extracts were safe for red blood cells, while 100% concentration of Euphorbia milii extract was toxic. The results suggest the potential use of these plants as supplements to enhance the effectiveness of antibiotics, with the importance of controlling the concentration to avoid toxic effects.
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