Evaluation of the relationship between diabetic neuropathy in type 2 diabetes mellitus, visfatin, adipsin, and oxidative stress biomarkers
DOI:
https://doi.org/10.54153/sjpas.2026.v8i2.1368Keywords:
Diabetic neuropathy, Adipsin , Visfatin, MDA, SOD, Catalase .Abstract
This study was conducted at Samarra General Hospital and private laboratories in Samarra City from early July 2025 to late November 2025. A total of 90 blood samples were collected and divided into three groups: a control group (n = 30), a type 2 diabetes mellitus (T2DM) group (n = 30), and a diabetic neuropathy group (n = 30), comprising men aged 40–80 years. The adipokines adipsin and visfatin were measured, along with oxidative stress marker malondialdehyde (MDA) and antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). The results showed a significant decrease in visfatin and a significant increase in adipsin in the diabetic neuropathy group compared with the control group (P ≤ 0.05). MDA levels were significantly elevated in both the diabetic neuropathy and T2DM groups relative to the control group. In addition, SOD and CAT activities were significantly decreased in the T2DM group compared with the control group (P ≤ 0.05). Overall, these findings suggest that the observed patterns of change in adipsin, visfatin, and oxidative stress indices may serve as supportive biomarkers for early screening of diabetic neuropathy, risk stratification, and monitoring of disease progression. The data also support therapeutic strategies targeting the reduction of oxidative burden as an adjunct approach to limit the progression of neuropathic complications.
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