Evaluation the level of Neprilysin and some hormones in polycystic ovarian syndrome patients

Abstract

Polycystic Ovary Syndrome (PCOS) is one of the most prevalent endocrine disorders among women of childbearing age. This study aims to know the effect of the syndrome on the level of neprilysin and some sex hormones. The study included 70 samples of women with PCOS, and twenty samples of healthy women of childbearing age. Samples were drawn twice for each case, the first in the follicular phase (The first week of the menstrual cycle) and the second in the luteal phase (after the third week of the menstrual cycle), the level of (PRG and Testosterone) in the patients was highlighted and the results were compared with control group. The activity of the renin-angiotensin-aldosterone system (RAAS) was also evaluated and the extent to which its variables were affected by this syndrome, as the level of angiotensin-converting enzyme 2 (ACE2) and neprelysin (Nep), which is an enzyme related to the system indirectly, was estimated. The results showed a significant decrease in the level of progesterone in the follicular and luteal phase in the female patients compared to the two control groups, and showed a significant increase in the level of both testosterone and ACE2, while neprilysin showed a significant difference between the control group and patients in the follicular phase. It was found that the renin-angiotensin system was affected by polycystic ovary syndrome.