Evaluation of the effectiveness of worker honey bee venom on laboratory mice with induced liver damage by Acetaminophen

Abstract

Apitherapy is an alternative treatment that relies on the use of honey bee products, the most important of which is bee venom, to treat many diseases that affect humans. The venom can be introduced into the human body through manual injection. Bee venom contains many active molecules such as peptides and enzymes that have beneficial uses in treating infections. The study was conducted to determine the effectiveness of bee venom on the tissues of laboratory mice in which hepatitis was induced by acetaminophen. The experiment was designed by taking (35) laboratory rats and divided into five groups, one control (fed), one injected with 300 mg/kg acetaminophen, and three groups with bee venom at concentrations (15, 30, 60 microliters). The results showed through examination that acetaminophen caused distinct damage to hepatic cells and led to infiltration of inflammatory cells and general tissue degeneration, in addition to damage to blood vessels. The results of the other groups were approximately the same degree of injury, while the group treated with bee (30 microliters) showed after a month that the hepatic cells Arranged almost uniformly around the central vein. It was concluded that bee venom has the ability to protect the liver from the damage of drugs that cause liver damage, or at least reduce its effects.