platelets levels and platelet to lymphocyte ratio in patients with Acute myeloid leukemia before and after chemotherapy
DOI:
https://doi.org/10.54153/sjpas.2025.v7i2.1014Keywords:
AML, Platelet, PLR, ChemotherapyAbstract
Acute Myeloid Leukemia is blood disorder that characterizing by the overproduction of abnormal cells (blasts) in bone marrow and affects the myeloid linages that responsible of production on normal blood cells the rapid growth of abnormal cells that impede the normal production of platelet and courses thrombocytopenia and bleeding tendency. The present study (50) samples were collected from bone marrow and from peripheral blood. According to results that platelets count and platelet crit in patients before treatment was significantly (p˂ 0.05) lower than in patients after treatment and below the lower limit of normal range. However, platelet-large cell ratio in patients group before treatment is significantly higher than in patients after treatment and above the upper limit of normal range. While platelet/lymphocyte ratio (PLR) reveals that this ratio in patients before treatment is 48.2 ± 68.6 which is significantly lower than 159.5 ± 117.2 in patients after treatment .The current study administrate that the chemotherapy impact on the levels of platelets and the influence the effect of patient's characters and subtypes on the platelets outcomes also the platelet to lymphocyte ratio could being prognostic factor that reflect the health status of patients and their response to treatment.
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