Evaluation of the effectiveness of isolated tannins and flavonoids from pomegranate peels on some liver and kidney functions

Abstract

        This study was conducted to explain the effect of the pomegranate peel and its isolated tannins and flavonoids from it against the oxidative stress induced by hydrogen peroxide in the local male rabbits. Isolation of tannins and flavonoids from pomegranate peel were carried out. The study design included five groups (6 rabbits for each): positive control group C+, with standard pellet diet; negative control group C- was given hydrogen peroxide with water at a 0.5% concentration for four weeks; group1 (G1) orally administrated daily dose 300 mg/kg/day of pomegranate peel crude for four weeks; group 2 (G2) orally administrated daily dose 300 mg/kg/day of isolated tannins extract for four weeks; group 3 (G3) orally administrated daily dose 300 mg/kg/day of isolated flavonoids extract for four weeks, also, G1, G2 and G3 were given hydrogen peroxide with water at a 0.5% concentration for four weeks. The results showed a significant increase in the glutathione level and a significant decrease in the Malone dialdehyde level in the groups dosed with the extracts compared with the negative control group, and an improvement in liver enzymes was observed in the groups dosed with the extracts through the significant decrease compared to the negative control group. As well as in kidney function through the significant decrease in the levels of urea, creatinine and uric acid in the groups dosed with extracts compared with the negative control group.