Synthesis, characterization of some sulfonamide derivatives and their anti-bacterial activity
DOI:
https://doi.org/10.54153/sjpas.2021.v3i2.214Keywords:
Sulphonamide, antibacterial activity, heterocyclic compoundsAbstract
The research includes preparation of sulfa amide derivatives containing amines and evaluating their biological efficacy. The compounds prepared are sulfa amides. Some of them were diagnosed by means of IR, 1H-NMR NMR-13C techniques, and they assessed the biological effectiveness of the compounds. The measurement was done on the basis of measuring the diameter of inhibition caused by bacterial isolates on the agricultural environment and showed high inhibition of some compounds, some of which were few against bacteria. One of the compounds showed great activity against E.coli with an inhibition radius of 18 mm while the other compound showed efficacy against E.coli and S. aureues. Inhibition radii of 17 and 7 mm, respectively. Another compound showed activity against S. pneumonia with an inhibition radius of 8 mm. Others, however, did not show efficacy against S. pneumonia and S. pyogenes.
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