Effect of Zn-nano-particles and aqueous extract of pomegranate peel on some biochemical parameters of rats infected with Rotavirus

Abstract

The effect of using nanoparticles and aqueous extract of pomegranate peel in treating rotavirus induced in laboratory rats was studied. The experiment was conducted at the animal house of the College of Veterinary Medicine -Tikrit University for the period from 18 February 2021 and by 20 April 2021 by using 28 rats that the age of rats ranged from two months and three months and the experimental animals were divided into three groups, the control group and not treated with any treatment substance. While the second group was treated with an ZnO nanoparticles, whereas the third group was treated with the aqueous extract of pomegranate peels. The study showed that there was no significant difference in the concentration of LDL-C between the three groups, while it was noted that the concentration of high-density lipoprotein-cholesterol HDL-C recorded a significant decrease in all treated groups when compared with the control group. As for the triglycerides, it was noted that the control group recorded The highest significant value when compared with the rest of the groups, while the treated groups did not differ among themselves. As for cholesterol level, it was noted that the treated groups recorded a significant decrease compared with control group, while the group treated with zinc nanoparticles recorded the lowest significant value when compared with other groups. As for liver enzymes (AST and ALT), we note that they recorded a significant increase in the group treated with zinc nanoparticles when compared with control group. The results also showed a significant decrease for the blood picture parameters for the group treated with zinc nanoparticles when compared with other study groups except for white blood cells, which recorded the highest significant value in the group treated with nanoparticles..