Effect of the chemical preservative Propyl 4-hydroxybenzoate on liver tissue in male albino rats

Abstract

The use of preservatives in the field of food allows the provision of types of food products and foods in the off-season,ةIt also allows pharmaceutical and cosmetic products to be used for long periods without being damaged by the growth of microorganisms. But recently, several disadvantages of these compounds have emerged, including parabens, which include Propyl 4-hydroxybenzoate, due to their frequent use due to their availability in large quantities, cheap prices, and easy access. Several concentrations (800, 400, 200) mg/kg/day were used in this study for 30 days. as these concentrations affected the liver tissue of adult white male rats. The concentration of 800 mg/kg had the greatest effect on it, as it led to hepatocyte hypertrophy and degeneration, and cellular infiltration. Lymphocytic, hemosiderin, and Kupffer cell hyperplasia.