Study the relationship of osteopontin with blood pressure in type II diabetics without and with renal failure
DOI:
https://doi.org/10.54153/sjpas.2024.v6i4.709Keywords:
osteopontin, Blood pressure, Type 2 diabetesAbstract
Elevated serum levels of Osteopontin(OPN) have been associated with Diabetic Nephropathy.Aim of the study was to investigate the relationship between OPN serum levels and blood pressure in Type 2 diabetes mellitus(T2DM) with and without Renal Failure.Methods:In this study, we measured serum levels of (OPN), Electrolytes(Na+ , k+), serum Phosphorous level(PO4) and Blood Pressure in 50 Patients among them, 25 diabetic patients without Renal Failure and 25 with Renal Failure and 30 control subjects .Results:This study found that serum OPN levels(ng/mL) were higher in T2DM without and with Renal Failure than in control group(6.219+0.732 vs4.611+1.296)(7.497+1.758 vs4.611+1.296)sequentially. The levels of DBP(mmHg) non-significant difference between T2DM without Renal Failure than in control group (82.8+15.14 vs86+10.03) and it was Lower in T2DM with Renal Failure than in control group(68.28+14.34 vs86+10.03).The SBP(mmHg) in three groups showed no significant difference (129.3+12.58vs128.4+19.72vs136.9+15.24).As for MAP non-significant difference between T2DM without Renal Failure than in control group(98+15.84vs100.4+9.65) and it was Lower in T2DM with Renal Failure than in control group(91.16+12.98 vs100.4+9.65 ).Conclusions:Serum OPN levels significantly increased in T2DM without and with Renal Failure patients comparison to healthy subjects .The blood pressure is represented by the DBP and MAP were significantly in T2DM without Renal Failure patients than in controls.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Notice
Authors retain copyright and grant the SJPAS journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in Samarra Journal of Pure and Applied Science.
The Samarra Journal of Pure and Applied Science permits and encourages authors to archive Pre-print and Post-print items submitted to the journal on personal websites or institutional repositories per the author's choice while providing bibliographic details that credit their submission, and publication in this journal. This includes the archiving of a submitted version, an accepted version, or a published version without any Risks.
