Comparison of levels BNP and NT-proBNP between heart failure patients and heart failure with COVID-19
DOI:
https://doi.org/10.54153/sjpas.2025.v7i3.1092Keywords:
Heart failure, Covid-19, NT-proBNP, Cardiac troponin, BNP ,IL-12,IL-10, and TNF-αAbstract
Comprehensive studies have been undertaken on biomarkers linked to coronavirus illness 2019 (COVID-19) in both healthy persons and those with diverse disorders, including cardiovascular diseases. The aim of the current study was to investigate B-Type Natriuretic Peptide (BNP), N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), Cardiac troponin, and certain cytokines, including Interleukin-10 (IL-10), Interleukin-12 (IL-12), and Tumor Necrosis Factors (TNF-α). Study was conducted from January 2022 to August 2022, with participants aged 18 to 68 years. The total number of subjects was 90 individuals: 35 patients with heart failure (G1), 33 of whom had heart failure with COVID-19 (G2), and 22 in the control group (G3). The specimens were obtained from General Kirkuk Hospital and Azadi Teaching Hospital. BNP (brain natriuretic peptide), NT-proBNP (N-terminal pro-BNP), IL-12, IL-10, and TNF-α. The present study showed increase NT-proBNP increased in both G1 and G2 as compared with G3 that were (216.39±24.43, 213.35±22.0, 169.50±23.30) respectively, at P-value <0.001. While BNP highly increased in G2, followed in G2 groups and decreased in control that were (172.25±21.46, 140.66 ± 21.24, 85.84 ± 26.89) respectively, at P-value <0.001. IL-12, TNF-a, IL-10 in G2 were (451.19±13.5, 144.1± 71.2, 192.0±25.5 ) as compared with control that were (350.07±22.03, 104.1± 144.1± 119.22±29.6)at p-value<0.05, This study found that covid-19 patients have higher NT-proBNP, BNP and interleukin-10,-12, and TNF-a levels, which indicate illness progression.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Notice
Authors retain copyright and grant the SJPAS journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in Samarra Journal of Pure and Applied Science.
The Samarra Journal of Pure and Applied Science permits and encourages authors to archive Pre-print and Post-print items submitted to the journal on personal websites or institutional repositories per the author's choice while providing bibliographic details that credit their submission, and publication in this journal. This includes the archiving of a submitted version, an accepted version, or a published version without any Risks.
